克罗米酚对男性低促性腺素性功能减退症必要

纽约（路透社健康初版）1同月四日报道：据发表在12同月出初版的《生育与不育》杂志的一项调查结果指出克罗米衍生物对部份偏高促性腺素性功能有增无减的成人病变有利。来自伯明翰查尔斯顿学院的该调查结果的第一作者Scott J. WhittenClark在给予路透通讯社采访时说：“继发性或于对HH病变在给予侵害性非常大和更为昂贵的疗法（例如注射促性腺激素类）前进行4个同月的克罗米衍生物早先疗法是有利的。”WhittenClark和熟人研究了克罗米衍生物对10名HH成人病变（HH是导致成人不育的相似因素）是否有效。调查结果称克罗米衍生物疗法1年后，4名沃特(氏)综合征病变中只有一名病变的精子浓度减少而全肾上腺功能有增无减症病变的精子缺乏症状均不能得到改善。相反，该调查结果指出3名成年复发的继发性HH成人病变经过3个同月克罗米衍生物的疗法精子浓度有了明显减少。在此之前该组病变已有两名完全恢复了哺育。WhittenClark说：“除非对克罗米衍生物疗法不能化学反应，我们不会因为副作用停止对病变使用该药物。”最后作者概述说：“因为条件依赖于，对HH病变促性腺激素类药物和克罗米衍生物的随机研究难于进行，然而利用多系列的完全符合选取规范对病变进行分级可能帮助进一步的测试克罗米衍生物完全恢复成人偏高哺育的有效性。 Male Hypogonadotropic Hypogonadism May Respond to Clomiphene CitrateBy Will Boggs, MDNEW YORK (Reuters Health) Jan 04 - Some men with hypogonadotropic hypogonadism (HH) benefit from treatment with clomiphene citrate, according to a report in the December issue of Fertility and Sterility.Patients with idiopathic or acquired HH "may benefit from a 4-month trial (of clomiphene citrate) before proceeding with more invasive and expensive therapies, such as injectable gonadotropins," lead author Dr. Scott J. Whitten, from University of Alabama at Birmingham, told Reuters Health.Dr. Whitten and colleagues investigated whether 10 men with HH, a rare cause of male infertility, might respond to treatment with clomiphene citrate.Only one of four patients with Kallmann's syndrome experienced an improvement in sperm concentration after 1 year of therapy with clomiphene citrate, the authors report, and no patient with panhypopituitarism experienced a reversal of azoospermia with clomiphene citrate treatment.In contrast, all three men with -onset idiopathic HH experienced significant increases in sperm concentrations and testosterone levels after 3 months of therapy with clomiphene citrate, the report indicates. Two pregnancies he been achieved in this subgroup so far."We did not he any of our patients discontinue the clomiphene because of side effects, only if there was lack of response," Dr. Whitten said."Because this is such a rare condition, additional randomized studies comparing gonadotropins with clomiphene in this subtype of HH patients would be difficult to perform," the authors conclude. "However, larger series using strict inclusion criteria for stratifying patients may be helpful to further examine the success of clomiphene treatment in restoration of this form of male subfertility."Fertil Steril 2006;86:1664-1668.

撰稿：粉红色未来世界

撰稿： 张靖